HP1(Tyr43) Polyclonal Antibody from Bioss Inc.

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Bioss Inc. for
HP1(Tyr43) Polyclonal Antibody

The HP1(Tyr43) Polyclonal Antibody from Bioss Inc. is a Rabbit Polyclonal antibody to Su(var)205, and Suppressor of variegation 205. This antibody recognizes Drosophila/Arthropod antigen. The HP1(Tyr43) Polyclonal Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, Immunohistochemistry - frozen, and Western Blot.

Description

HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin